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358 This metabolic process results in an increased concentration of nucleotides, triggering feedback mechanisms that suppress the synthesis of purines
This change in 7-nAChR occurred with an increase of pro-inflammatory mediators and reduced levels of NRF2 and HO-1 (Xue et al
V.McKayS
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Furthermore, NRF2 accelerates cellular redox homeostasis by upregulating the transcriptional regulation of multiple NADPH-generating enzyme genes (e.g., G6PD) [26]
References: BMJ
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